Dwight J Klemm Selected Research

Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)

4/2014	Targeting mitochondria to restore failed adaptation to exercise in diabetes.
12/2013	Inhibition of phosphatidylinositol 3-kinase/Akt signaling attenuates hypoxia-induced pulmonary artery remodeling and suppresses CREB depletion in arterial smooth muscle cells.
8/2011	Reduction of reactive oxygen species prevents hypoxia-induced CREB depletion in pulmonary artery smooth muscle cells.
4/2010	CREB downregulation in vascular disease: a common response to cardiovascular risk.
7/2006	Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells.

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Dwight J Klemm Research Topics

Disease

10	Hypoxia (Hypoxemia) 04/2020 - 12/2005
6	Obesity 01/2022 - 05/2007
6	Pulmonary Hypertension 04/2020 - 07/2006
3	Hypertrophy 04/2020 - 08/2011
3	Insulin Resistance 07/2013 - 04/2010
3	Vascular Remodeling 01/2013 - 04/2007
2	Cardiovascular Diseases (Cardiovascular Disease) 11/2021 - 04/2014
2	Hypertension (High Blood Pressure) 02/2015 - 04/2010
1	Body Weight (Weight, Body) 01/2022
1	Dyslipidemias (Dyslipidemia) 11/2021
1	Metabolic Diseases (Metabolic Disease) 11/2021
1	Right Ventricular Hypertrophy 04/2020
1	Tuberous Sclerosis (Bourneville's Disease) 11/2019
1	Fibrosis (Cirrhosis) 06/2017
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2016
1	Blast Crisis (Blast Phase) 01/2016
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2016
1	Type 2 Diabetes Mellitus (MODY) 02/2015
1	Hypoventilation 12/2014
1	Hyperlipidemias (Hyperlipidemia) 12/2014
1	Pulmonary Arterial Hypertension 12/2014
1	Lung Injury 10/2014
1	Vascular System Injuries 04/2010
1	Atherosclerosis 04/2010
1	Hyperplasia 03/2009
1	Carcinogenesis 03/2009
1	Inflammation (Inflammations) 03/2009
1	Fatty Liver 05/2007
1	HIV Infections (HIV Infection) 01/2006
1	Atrophy 01/2006
1	Lipodystrophy 01/2006

Drug/Important Bio-Agent (IBA)

5	Transcription Factors (Transcription Factor)IBA 04/2020 - 04/2010
5	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 04/2014 - 07/2006
2	CollagenIBA 04/2020 - 12/2013
2	Bleomycin (Blenoxane)FDA LinkGeneric 06/2017 - 10/2014
2	CateninsIBA 06/2017 - 01/2013
2	CytokinesIBA 12/2014 - 07/2013
2	Oxidants (Oxidizing Agents)IBA 12/2014 - 08/2011
2	fasudil (AT 877)IBA 12/2013 - 04/2007
2	rho-Associated KinasesIBA 12/2013 - 04/2007
2	Phosphatidylinositols (Phosphatidylinositol)IBA 07/2013 - 10/2012
2	Rosiglitazone (Avandia)FDA Link 05/2010 - 04/2007
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2022
1	AdipokinesIBA 01/2022
1	Pharmaceutical PreparationsIBA 11/2021
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2021
1	Conditioned Culture MediaIBA 04/2020
1	Extracellular Matrix ProteinsIBA 04/2020
1	Sirolimus (Rapamycin)FDA Link 11/2019
1	Tuberous Sclerosis Complex 2 ProteinIBA 11/2019
1	GATIBA 01/2016
1	Biological ProductsIBA 01/2016
1	SirtuinsIBA 02/2015
1	saxagliptin FDA Link 02/2015
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 02/2015
1	LipidsIBA 12/2014
1	Blood Glucose (Blood Sugar)IBA 12/2014
1	Insulin (Novolin)FDA Link 12/2014
1	EnzymesIBA 12/2013
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 12/2013
1	ChemokinesIBA 10/2012
1	Phosphotransferases (Kinase)IBA 10/2012
1	tempolIBA 08/2011
1	Superoxide DismutaseIBA 08/2011
1	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2011
1	Small Interfering RNA (siRNA)IBA 08/2011
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 08/2011
1	ElastinIBA 08/2011
1	MitogensIBA 08/2011
1	ThiazolidinedionesIBA 05/2010
1	Troglitazone (Rezulin)FDA Link 05/2010
1	2,4-thiazolidinedione (thiazolidinedione)IBA 05/2010
1	Casein Kinase II (Casein Kinase 2)IBA 05/2010
1	LDL Lipoproteins (beta Lipoproteins)IBA 04/2010
1	LDL Receptors (LDL Receptor)IBA 04/2010
1	oxidized low density lipoproteinIBA 04/2010
1	Neprilysin (Neutral Endopeptidase)IBA 03/2009
1	NeuropeptidesIBA 03/2009
1	CCAAT-Enhancer-Binding Protein-betaIBA 05/2007
1	Becaplermin (PDGF-BB)FDA Link 07/2006
1	NucleosidesIBA 01/2006
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2006
1	Reverse Transcriptase InhibitorsIBA 01/2006
1	PPAR-gamma AgonistsIBA 12/2005

Therapy/Procedure

1	Contraindications 12/2016